Product Details
| Product Name:
TZ9 |
CAS No.:
1002789-86-7 |
| Purity:
99.69% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | TZ9 |
| Description | TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis. |
| In vitro | In MDA-MB-231 cells, TZ9 (Rad6B SMI #9) inhibits proliferation and migration when administered at concentrations ranging from 0.5 to 100 μM for 72 hours[1].
Cell-cycle progression delay is observed in MDA-MB-231 cells treated with TZ9 at concentrations ranging from 0.1 to 5 μM over a period of 24 to 72 hours[1].
Apoptosis induction is noted in MDA-MB-231 cells exposed to TZ9 at a concentration of 5 μM for 8 to 48 hours[1].
In MDA-MB-231 cells, TZ9 exhibits inhibitory effects on H2A ubiquitination and downregulates levels of PCNA and β-catenin protein when applied at concentrations of 0.5, 1, 2.5, and 5 μM for 24 hours[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (109.19 mM)
|
| Keywords | TZ-9 | TZ 9 | TZ9 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States