TRV-120027 TFA NEW
| Price | $38 | $119 | $189 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: TRV-120027 TFA | Purity: 97.45% |
| Supply Ability: 10g | Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | TRV-120027 TFA |
| 描述 | TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ?-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. |
| 體外活性 | Treatment of 100 nM TRV-120027 TFA induces an [Ca2+]i increase in HEK293 cells co-transfected with AT1R, β-arrestin-1, and TRPC3, which are significantly blocked by Pyr3 pre-incubation in HEK293 cells co-transfected with Flag-AT1R-Cherry, HA-β-arrestin-1, and TRPC3-GFP[1]. Treatment of 100 nM TRV-120027 TFA significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, HA-β-arrestin-1 and TRPC3-GFP[1]. |
| 體內(nèi)活性 | TRV-120027 TFA combined with furosemide decreases cardiac preload and afterload, systemic and renal vascular resistances, and left ventricular external work while increasing cardiac output and renal blood flow[2]. |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 88 mg/mL (84.61 mM) |
| 關(guān)鍵字 | 1234510-46-3 | TRV 120027 TFA | 1234510-46-3 free base | TRV120027 TFA | TRV-120027 TFA |
| 相關(guān)產(chǎn)品 | (+)-Camphor | Losartan potassium | Tranilast | Camphor | Pregnenolone | Sacubitril/Valsartan | 1,4-Cineole | trans-Cinnamaldehyde | Irbesartan | Losartan | Ramipril | Captopril |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 多肽分子庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗心血管疾病化合物庫 | 內(nèi)分泌激素分子庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 離子通道庫 | 抗高血壓化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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