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Postion:Product Catalog >TRPM8 antagonist 2
TRPM8 antagonist 2
  • TRPM8 antagonist 2

TRPM8 antagonist 2 NEW

Price $30 $64 $106
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: TRPM8 antagonist 2 CAS No.: 259674-19-6
Purity: 98.10% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameTRPM8 antagonist 2
DescriptionTRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
In vitroTRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in neuropathic pain research. It effectively inhibits menthol-induced increases in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells expressing the rat TRPM8 isoform (IC50, 40 nM).
In vivoTRPM8 antagonist 2, administered subcutaneously at doses of 1, 10, and 30 mg/kg, demonstrates significant, dose-dependent antinociceptive effects and reduces wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at the 30 mg/kg dosage. Additionally, at lower doses of 0.1 and 1 μg, it effectively mitigates Oxaliplatin (OXP)-induced cold allodynia in mice.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 160 mg/mL (401.51 mM)
KeywordsTRPM8 antagonist 2 | inhibit | Transient receptor potential channels | TRP Channel | Inhibitor | TRPM-8 antagonist 2
Inhibitors Related(+)-Camphor | AP 18 | Methyl syringate | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Methyl salicylate | SKF-96365 hydrochloride
Related Compound LibrariesTarget-Focused Phenotypic Screening Library | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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