Trifluridine NEW
Price | $30 | $46 | $65 |
Package | 10mg | 25mg | 50mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: Trifluridine | CAS No.: 70-00-8 |
Purity: 99.82% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | Trifluridine |
Description | Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. |
In vitro | Differences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells. |
In vivo | Differences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 14.8 mg/mL (50 mM) DMSO : 55 mg/mL (185.69 mM), Sonication is recommended. |
Keywords | TFT | Thymidylate Synthase | Nucleoside Antimetabolite/Analog | Herpes simplex virus | inhibit | Inhibitor | Trifluridine | HSV | NSC529182 | NSC-529182 | NSC-75520 | Orthopoxvirus | NSC75520 |
Inhibitors Related | Stavudine | Rifampicin | 5-Fluorouracil | Guanidine hydrochloride | 2,4-D | Oxyresveratrol | Thymidine | Temozolomide | Folic acid |
Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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