Traxoprodil NEW
| Price | $47 | $64 | Get Latest Price |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Traxoprodil | CAS No.: 134234-12-1 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Traxoprodil |
| Description | Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). |
| Animal Research | The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2]. |
| In vivo | Traxoprodil exhibits potent activity by effectively blocking haloperidol-induced catalepsy at doses below 1 mg/kg and counteracting NMDA-induced c-fos induction in mice at a 1 mg/kg dosage [1]. Additionally, traxoprodil demonstrates antidepressant properties in the forced swim test at doses of 20 and 40 mg/kg without affecting locomotor activity in animals [2]. Furthermore, at a concentration of 20 nM administered intracerebroventricularly (i.c.v.), traxoprodil prolongs the onset of generalized tonic-clonic seizures triggered by PTZ (70 mg/kg; i.p.). At an oral dose of 60 mg/kg, it not only delays the initiation of clonic and generalized seizures but also reduces the total duration of seizures experienced [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 0.1 mg/mL (insoluble) DMSO : 62.5 mg/mL (190.89 mM), Sonication is recommended. |
| Keywords | iGluR | Ionotropic glutamate receptors | CP-101606 | inhibit | CP 101606 | Traxoprodil | Inhibitor |
| Inhibitors Related | Mephenesin | L-Glutamic acid | glycine | Halothane | L-Glutamic acid monosodium salt | Riluzole | Linalool | O-Phospho-L-serine | Procaine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00/25mg |
VIP1Y
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TargetMol Chemicals Inc.
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2024-10-28 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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