Product Details
| Product Name:
Topterone |
CAS No.:
60607-35-4 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | Topterone |
| Description | Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters. |
| In vivo | To determine its endocrine profile, Topterone is administered parenterally or topically to rats, rabbits, or hamsters. Systemic administration reveals that Topterone exhibits both antiandrogenic and progestational effects. However, topical application at a dose of 1 g/kg/day fails to induce a systemic antiandrogenic response, and only a minimal progestational response is observed at 32 mg/kg/day. No other endocrine activities are detected in these experiments[2].
Topterone demonstrates the inhibition of flank organ development in castrated immature male hamsters in response to both testosterone and dihydrotestosterone, whereas Progesterone inhibits stimulation by only testosterone. Furthermore, topical application of Topterone has been shown to cause regression in the development of the flank organ[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Topterone |
| Inhibitors Related | Dehydroisoandrosterone 3-acetate | S-23 | Allura Red AC | Sunset Yellow FCF | Flutamide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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