Tolmetin sodium NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Tolmetin sodium | CAS No.: 35711-34-3 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Tolmetin sodium |
| Description | Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID). Tolmetin sodium is an orally active and potent inhibitor of COX with IC 50s of 0.35 μM for human COX-1 and 0.82 μM for human COX-2, respectively [1] [2]. |
| In vitro | Tolmetin sodium at a concentration of 0.25 mM does not reduce lipid peroxidation in rat brain homogenate. However, Tolmetin at concentrations ranging from 0.25 to 1 mM exhibits antioxidant properties by scavenging free radicals, yet it does not induce the generation of superoxide anions in rat brain homogenate [3]. Additionally, Tolmetin sodium demonstrates dose-dependent anticancer effects against the HT-29 colon cancer cell line within the concentration range of 0.001-100 μM [4]. In contrast, concentrations of Tolmetin sodium up to 100 μM have no impact on the growth of osteoblasts [5]. |
| In vivo | Tolmetin sodium, administered at dosages of 30-100 mg/kg via gavage either as a single dose or twice daily for 3 and 14 days, exhibits its peak ulcerogenic effect in male Wistar rats (180-200 g) four hours post initial dose. This effect notably diminishes following repeated administration over 3 and 14 days. Furthermore, tolmetin is associated with gastric lesions at 100 mg/kg [2]. Pre-treatment with tolmetin sodium at 5 mg/kg, administered twice daily for 5 days, significantly mitigates quinolinic acid (QA)-induced neurotoxicity [3]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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