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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Protein tyrosine kinase /JAK / STAT>JAK inhibitors>Tofacitinib
Tofacitinib
  • Tofacitinib
  • Tofacitinib
  • Tofacitinib

Tofacitinib

Price $3000
Package 1kg
Min. Order: 1kg
Supply Ability: 1ton
Update Time: 2022-07-19

Product Details

Product Name: Tofacitinib CAS No.: 477600-75-2
Min. Order: 1kg Purity: 99.50%
Supply Ability: 1ton Release date: 2022/07/19

In November 2012, the US FDA approved tofacitinib (also referred to as CP-690550) for the treatment of adult patients with moderate to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate. Tofacitinib is the first small molecule kinase inhibitor approved for the treatment of RA. Tofacitinib is an inhibitor of the four subtypes of Janus kinase (JAK): JAK1, JAK2, JAK3, and Tyk2. The JAKs are intracellular, nonreceptor tyrosine kinases that play important roles in the signal transduction pathway of many cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) and are involved in the propagation of inflammation in RA. Tofacitinib acts by inhibiting the phosphorylation and activation of signal transducers and activators of transcription (STATs), thereby suppressing the production of inflammatory mediators in joint tissue. At the enzyme level, tofacitinib inhibits JAKs 1, 2, 3, and Tyk2 with IC50s of 3.2, 4.1, 1.6, and 34 nM, respectively. At the cellular level, tofacitinib inhibits the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50s of 406, 56, and 1377 nM, respectively.

Company Profile Introduction

Changsha Junyu Chemexpress Co., Ltd. is a high-tech enterprise established in 2012 in Liuyang National Economic and Technological Development Zone, Hunan Province. The company is mainly engaged in the research and development of related compounds in the development of new drugs, as well as the research and development, production and sales of advanced intermediates, characteristic pharmaceutical APIs and high-end reagents. At the same time, the company also provides domestic and foreign pharmaceutical enterprises with commissioned development of new drugs and generic drugs, drug certification application, production technology improvement services. Featured services include: chiral drug technology development and active molecule library development. The company follows the standard modern enterprise operation and management system, and has established the organizational structure of scientific decision-making, reasonable division of labor, smooth communication and clear responsibility. According to the actual management needs, the company will technology, product development, quality, market and logistics for a scientific and organic combination. Our equipment and hardware conditions are fully capable of meeting the production needs of the industrialization of various projects. The company pays attention to the introduction and training of professional technical personnel, and has a strong core technology development team composed of technical research and development personnel, specializing in the technical research, development and design of biomedical chemical products. At the same time, the company has established a good cooperative relationship with the School of Chemistry, Biology and Biotechnology of Peking University, relying on the strong scientific research background of the School of Chemistry and Biotechnology of Peking University to develop future projects. We rely on advanced equipment and strict management, dedicated to provide every customer with

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  • Since: 2012-10-31
  • Address: Room 1 0 3 , pha s e I I I , sc i e nc e a nd te c hnol og y e ntr e pr e ne ur s hi p c e nte r,
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