Product Details
| Product Name:
TM5441 |
CAS No.:
1190221-43-2 |
| Purity:
99.09% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | TM5441 |
| Description | TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.It induces intrinsic cell death in several human cancer cells and attenuates Nω-nitro-1-arginine methyl ester-induced cardiac hypertension and vascular senescence. |
| Kinase Assay | TM5441 is dissolved with DMSO at a stock concentration of 50 mM.HT1080, HCT116, Daoy, MDA-MB-231 and Jurkat cells are treated with 0-100 μM TM5441 for 48 hours at 37°C. Cell viability is measured by MTT assay. |
| Animal Research | TM5441 is prepared in 0.5% carboxymethyl cellulose.Mice: TM5275 at 50 mg/kg/day and TM5441 at 10 mg/kg/day were orally administered in control and diabetic mice for 16 weeks. Mice were monitored at least once a day. At the end, blood is collected for measurement of plasma glucose and creatinine, urine for protein measurement, and kidneys for immunohistochemical analysis. |
| In vitro | METHODS: TM5441 (1-100μM) was used to further study the survival of HT1080, HCT116, Daoy, MDA-MB-231 and Jurkat.
RESULTS Cell viability treated with TM5441 significantly decreased in a dose-dependent manner by 50%, ranging between 13.9 and 51.1μM.[2]
METHODS: Cultures of human endothelial cells EA.hy926 were pretreated with TM5441 (10 μM) for 24 h and then treated with doxorubicin (Dox) in triplicate for 4 days. Total protein and RNA were collected from three independently treated wells and combined to explore the protective effect of TM5441 on Dox-induced cellular senescence.
RESULTS TM5441 treatment inhibited Dox-induced expression levels of p53, PAI-1, p16, p21 and IGFBP3 in human endothelial cells. [3] |
| In vivo | METHODS: High-fat diet (HFD)-fed C57BL/6J mice were treated with 20 mg/kg of TM5441 daily to study the effect of TM5441, an oral PAI-1 inhibitor that lacks bleeding risk, on HFD-induced NAFLD.
RESULTS Early and delayed treatment with TM5441 reduced hepatic steatosis, and both strategies abolished hepatic insulin resistance and mitochondrial dysfunction, manifested by enhanced p-Akt and p-GSK3β, reduced p-JNK signaling, and p-AMPK and PGC-1α activation. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble）
|
| Keywords | TM5441 | PAI-1 | Plasminogen activator inhibitor-1 | Inhibitor | TM 5441 | TM-5441 | inhibit | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Inhibitor Library | Metabolism Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1KG |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-08 |
United States