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Postion:Product Catalog >API>Nervous system drugs>Tianeptine acid
Tianeptine acid
  • Tianeptine acid
  • Tianeptine acid
  • Tianeptine acid

Tianeptine acid NEW

Price $1
Package 1KG
Min. Order: 0.01KG
Supply Ability: 10000
Update Time: 2025-06-19

Product Details

Product Name: Tianeptine acid CAS No.: 66981-73-5
Min. Order: 0.01KG Purity: 99%
Supply Ability: 10000 Release date: 2025/06/19

Article illustration

Chemical Name:Tianeptine acid

Molecular Formula C??H??ClN?O?S

Molecular Weight 412.95 g/mol

CAS Number:66981-73-5

Appearance:White to off-white crystalline powder

Solubility - Soluble: DMSO, methanol, ethanol.

- Insoluble: Water (unlike sodium salt).

pKa:~4.7 (carboxylic acid group)

Storage:2–8°C, protected from light and moisture

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ParameterSpecificationTest MethodResult
1. Identification


- Chemical Name7-[(3-Chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acidHPLC/IR/NMRComplies
- CAS No.66981-73-5-66981-73-5
2. Physical Properties


- AppearanceWhite to off-white crystalline powderVisual inspectionComplies
- SolubilitySoluble in DMSO/ethanol; insoluble in waterUSP <1231>Complies
3. Purity & Assay


- Assay (HPLC)≥98.0% (anhydrous basis)HPLC (USP <621>)98.5%
- Related SubstancesIndividual impurity ≤0.5%; Total ≤1.5%HPLC (ICH Q3A)0.8% (max)
4. Water Content≤1.0% (Karl Fischer)USP <921>0.6%
5. Residual Solvents
USP <467>
- Methanol≤3000 ppmGC<500 ppm
- Dichloromethane≤600 ppmGCNot detected
6. Heavy Metals≤20 ppm (as Pb)USP <231> / ICP-MS<5 ppm
7. Melting Point140–145°CUSP <741>142°C
8. pH (Suspension)3.0–5.0 (1% in 50% ethanol)USP <791>4.2
9. Loss on Drying≤1.5%USP <731>0.9%

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Introduction:

Tianeptine Acid is the free acid form of tianeptine, a tricyclic antidepressant agent with a unique mechanism of action. Unlike its sodium salt counterpart (tianeptine sodium), it lacks the ionic sodium group, making it less soluble in water but more suitable for certain pharmaceutical formulations.


Tianeptine Acid vs. Tianeptine Sodium

Property Tianeptine Acid                               Tianeptine Sodium

Form Free acid                                                Sodium salt

Solubility Low water solubility                Freely soluble in water

Use Synthetic intermediate, research Direct pharmaceutical API

Stability Sensitive to humidity                More stable in aqueous formulations


Company Profile Introduction

Wuhan Hao Rong Biotechnology Co., Ltd., located in East Lake high tech Development Zone, Wuhan, is a company specializing in the production and operation of chemical raw materials, flavors and fragrances, food additives, agrochemicals and other products. The company has first-class production equipment, advanced production technology, scientific management system, perfect detection means, and an excellent R & D team. The R & D center of the company has a technical team specialized in research and development, as well as a number of advanced detection, experiment and pilot equipment, and has established a good technical support relationship with a number of scientific research institutions, with strong technical force. The company has a wide range of products, in line with the quality of survival, service and development, customer-centric, integrity management philosophy, do our best to provide customers with quality and cheap raw materials. In addition, haorong also helps customers develop and implement customized system solutions. In these core areas of the chemical industry, haorong's core expertise covers chemicals and application technology, flexible asset management and customized services.

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