
Tianeptine acid NEW
Price | $1 |
Package | 1KG |
Min. Order: | 0.01KG |
Supply Ability: | 10000 |
Update Time: | 2025-06-19 |
Product Details
Product Name: Tianeptine acid | CAS No.: 66981-73-5 |
Min. Order: 0.01KG | Purity: 99% |
Supply Ability: 10000 | Release date: 2025/06/19 |
Chemical Name:Tianeptine acid
Molecular Formula C??H??ClN?O?S
Molecular Weight 412.95 g/mol
CAS Number:66981-73-5
Appearance:White to off-white crystalline powder
Solubility - Soluble: DMSO, methanol, ethanol.
- Insoluble: Water (unlike sodium salt).
pKa:~4.7 (carboxylic acid group)
Storage:2–8°C, protected from light and moisture
Parameter | Specification | Test Method | Result |
---|---|---|---|
1. Identification | |||
- Chemical Name | 7-[(3-Chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid | HPLC/IR/NMR | Complies |
- CAS No. | 66981-73-5 | - | 66981-73-5 |
2. Physical Properties | |||
- Appearance | White to off-white crystalline powder | Visual inspection | Complies |
- Solubility | Soluble in DMSO/ethanol; insoluble in water | USP <1231> | Complies |
3. Purity & Assay | |||
- Assay (HPLC) | ≥98.0% (anhydrous basis) | HPLC (USP <621>) | 98.5% |
- Related Substances | Individual impurity ≤0.5%; Total ≤1.5% | HPLC (ICH Q3A) | 0.8% (max) |
4. Water Content | ≤1.0% (Karl Fischer) | USP <921> | 0.6% |
5. Residual Solvents | USP <467> | ||
- Methanol | ≤3000 ppm | GC | <500 ppm |
- Dichloromethane | ≤600 ppm | GC | Not detected |
6. Heavy Metals | ≤20 ppm (as Pb) | USP <231> / ICP-MS | <5 ppm |
7. Melting Point | 140–145°C | USP <741> | 142°C |
8. pH (Suspension) | 3.0–5.0 (1% in 50% ethanol) | USP <791> | 4.2 |
9. Loss on Drying | ≤1.5% | USP <731> | 0.9% |
Introduction:
Tianeptine Acid is the free acid form of tianeptine, a tricyclic antidepressant agent with a unique mechanism of action. Unlike its sodium salt counterpart (tianeptine sodium), it lacks the ionic sodium group, making it less soluble in water but more suitable for certain pharmaceutical formulations.
Tianeptine Acid vs. Tianeptine Sodium
Property Tianeptine Acid Tianeptine Sodium
Form Free acid Sodium salt
Solubility Low water solubility Freely soluble in water
Use Synthetic intermediate, research Direct pharmaceutical API
Stability Sensitive to humidity More stable in aqueous formulations
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