Thymidine NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Thymidine | CAS No.: 50-89-5 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Thymidine |
| Description | Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase. |
| In vitro | METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Thymidine (300-1200 μM) and H2O2 (1 mM) for 0.5 h. DNA damage was detected by comet assay. RESULTS: For the control and Thymidine alone groups, the samples appeared almost circular due to the absence of DNA damage. After exposure to 1.0 mM H2O2 for 0.5 h, a clear comet was observed, indicating DNA damage in this group. However, there was a decreasing trend in the extent of DNA damage in the three combination groups as the concentration of Thymidine pretreatment increased. [1] METHODS: Jurkat, MOLT4 and NALM6 cells were treated with Thymidine (2 mM) for 18 h. RESULTS: Thymidine arrests the cell cycle at the G1/S boundary. [2] |
| In vivo | METHODS: To investigate the effects of folate analogs on superantigen-reactive peripheral T cells in vivo, Thymidine (500 mg/kg) was injected intraperitoneally into MTX- or tomudex-administered mice twice daily for ten days. RESULTS: Both MTX and tomudex blocked the expansion and accelerated the peripheral clearance of Vβ8-selective T cells. Thymidine administration completely eliminated this effect, suggesting that inhibition of glycoside synthase (TS), but not other folate-dependent enzymes, is the predominant mechanism. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Saline : 25 mg/mL (103.21 mM) Ethanol : Soluble DMSO : 50 mg/mL (206.42 mM) Pyridine, Methanol, etc. : Soluble |
| Keywords | DNA/RNA Synthesis | Endogenous Metabolite | DNA | NSC21548 | arrest | synchronizing | replication | Inhibitor | NSC-21548 | Thymidine | precursor | inhibit |
| Inhibitors Related | Sucrose | Daidzein | Ferulic Acid | Glycerol |
| Related Compound Libraries | Marine Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | EMA Approved Drug Library | Natural Product Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36?Washington?Street, Wellesley?Hills
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