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Postion:Product Catalog >TH-Z835
TH-Z835
  • TH-Z835

TH-Z835 NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: TH-Z835 CAS No.: 2766209-50-9
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameTH-Z835
DescriptionTH-Z835 is a mutant-selective KRAS(G12D) inhibitor with an IC50 of 1.6 μM.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange.
In vitroTH-Z835 reduces pERK levels in PANC-1 cells with an IC50 value less than 2.5 μM [1]. Additionally, TH-Z835 exhibits antiproliferative effects in various non-G12D mutant cancer cell lines, including 4T1 (KRAS(WT)), MIA PaCa-2 (KRAS(G12C)), CFPAC-1 (KRAS(G12V)), and HCT116 (KRAS(G13D)), by decreasing pERK and pAKT levels and inducing apoptosis, indicating off-target effects [1].
In vivoTH-Z835 (10mg/kg; intraperitoneal injection) reduces tumor volume in a C57BL/6 mouse model. In vivo, TH-Z835 induces apoptosis and inhibits MAPK signaling [1].
StorageShipping with blue ice.
Inhibitors RelatedAdagrasib | (S)-AMG-510 | BI-2493 | CCG-257081 | Ketoconazole | Deltarasin | MRTX1133 | Salirasib | RMC-6236 | (S)-(-)-Perillyl alcohol | CASIN | Sotorasib

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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Recommended supplier

Product name Price   Suppliers Update time
$67.00/2mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-22
$39.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
$1.00/10G
Wuhan Boyuan Import & Export Co., LTD
2018-08-06
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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