TG 100572 Hydrochloride NEW
| Price | $399 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: TG 100572 Hydrochloride | CAS No.: 867331-64-4 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | TG 100572 Hydrochloride |
| Description | TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively). |
| In vitro | apoptosis in rapidly proliferating, but not quiescent, endothelial cell cultures induced by TG 100572[1]. TG 100572 is shown to inhibit hRMVEC cell proliferation(IC50 of 610±72 nM). TG 100572 has the therapeutic potential to inhibit VEGF function in ocular endothelial cells, a contributing factor to pathological angiogenesis in diseases such as AMD and PDR[2]. |
| In vivo | Systemic delivery of TG 100572 in a murine model of laser-induced choroidal neovascularization (CNV) significantly suppresses CNV, but is associated with weight loss indicative of systemic toxicity[1]. TG 100572 (23.4 μM) reaches the choroid and sclera within 30 minutes (Tmax = 0.5 h), with relatively low levels in the retina. Due to its short half-life in ocular tissues, TG 100572 is administered topically at least t.i.d. to maintain appropriate eye levels. The maximum concentration achievable in formulations is 0.7% w/v[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 20 mg/mL (39.03 mM), Sonication is recommended. |
| Keywords | Vascular endothelial growth factor receptor | FGFR | TG100572 | PDGFR | Inhibitor | TG 100572 | VEGFR | Platelet-derived growth factor receptor | inhibit | TG 100572 Hydrochloride | Fibroblast growth factor receptor | TG-100572 | TG100572 Hydrochloride | TG-100572 Hydrochloride | Src |
| Inhibitors Related | Ribociclib | Amlexanox | Nintedanib | Regorafenib monohydrate | Sorafenib | Ferulic Acid | Regorafenib | Sorafenib tosylate | Formononetin | Imatinib | Pazopanib | Axitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00/25mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $0.00/1kg |
VIP1Y
|
BINBO BIOLOGICAL CO.,LTD
|
2024-04-11 | |
| $399.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY