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Postion:Product Catalog >API>Anesthetic Agents>Local anesthetics>Tetracaine hydrochloride
Tetracaine hydrochloride
  • Tetracaine hydrochloride
  • Tetracaine hydrochloride
  • Tetracaine hydrochloride
  • Tetracaine hydrochloride
  • Tetracaine hydrochloride

Tetracaine hydrochloride NEW

Price Get Latest Price
Package 1KG 5KG 25KG
Min. Order: 1KG
Supply Ability: 20 T each week
Update Time: 2023-08-16

Product Details

Product Name: Tetracaine hydrochloride CAS No.: 136-47-0
EC-No.: 205-248-5 Min. Order: 1KG
Purity: 98%~99% Supply Ability: 20 T each week
Release date: 2023/08/16

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Product Name:Tetracaine hydrochloride
Synonyms:L AND OCAIN HYDROCHLORIDE;INTERCAIN HYDROCHLORIDE;MEETHOBALM HYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER HYDROCHLORIDE;4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE;4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL;4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HYDROCHLORIDE;AMETHOCAINE HYDROCHLORIDE
CAS:136-47-0
MF:C15H25ClN2O2
MW:300.82
EINECS:205-248-5
Product Categories:Local anesthetic;PONTOCAINE;Analgesic series;API,RAW;research chemical;API;API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;API;136-47-0
Mol File:136-47-0.mol
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Tetracaine hydrochloride Chemical Properties
Melting point 149°C
density 1.1279 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. 2-8°C
solubility alcohol: solublesoluble 40 parts of solvent
pka8.39(at 25℃)
form neat
color White to Almost white
Water Solubility Soluble in water at 50mg/ml
Merck 14,9188
InChIInChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
InChIKeyPPWHTZKZQNXVAE-UHFFFAOYSA-N
SMILESC1(C=CC(NCCCC)=CC=1)C(=O)OCCN(C)C.Cl
LogP3.649 (est)
CAS DataBase Reference136-47-0(CAS DataBase Reference)
EPA Substance Registry SystemTetracaine hydrochloride (136-47-0)

Safety Information
Hazard Codes T
Risk Statements 25-36-43-42/43
Safety Statements 26-36/37-45-36/37/39-22-53
RIDADR 2811
WGK Germany 3
RTECS DG4900000
HazardClass 6.1
PackingGroup III
HS Code 29224999
ToxicityLD50 i.p. in mice: 70 mg/kg (Dawes); also reported as LD50 in female mice (mg/kg): 13 i.v.; 35 s.c. (Bopp)
MSDS Information
ProviderLanguage
Tetracaine hydrochlorideEnglish

Tetracaine hydrochloride Usage And Synthesis
Chemical PropertiesTetracaine hydrochloride is a white, crystalline powder, odourless; hygroscopic; it has a slightly bitter taste and causes local numbness after being placed on the tongue. Soluble in water, soluble in ethanol (~750 g/l), practically insoluble in ether. even in the absence of light, it is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures.
OriginatorAnestesia topica,Miro
UsesTetracaine hydrochloride is a local anesthetic used topically in opthalmology.It is a highly effective local anesthetic that reversibly blocks nerve function. It is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthesia effect is remarkable. Tetracaine hydrochloride has been widely used in clinical practice.
DefinitionChEBI: Tetracaine hydrochloride is a benzoate ester. It is a potent local anesthetic of the ester type used for surface and spinal anesthesia.
ApplicationTetracaine hydrochloride is also known as ropivacaine hydrochloride, pantocaine, pantocaine and four ropivacaine hydrochloride. It is easily soluble in water and ethanol, but insoluble in ether, benzene. Tetracaine hydrochloride is a local anesthetic with long-acting ester. In addition, procaine is widely used in clinical, but because of its poor permeability and poor narcotic performance, a small tetracaine was found in 1930 found.
Tetracaine hydrochloride can be used for topical anesthesia, and 0.05%-0.1% tetracaine hydrochloride can provide long-term and good effect of surface anesthesia. Meanwhile, tetracaine hydrochloride is still widely used in ophthalmic surface anesthesia, which has a long time for surface anesthesia and sensory resistance.
PreparationSynthesis of tetracaine hydrochloride using 4-Methyl-2-pentanone as starting material: To the reaction kettle, first add 320.0kg of methyl isobutyl ketone, then add 40.0kg (207mol) of 4-Butylaminobenzoic acid and 56.8kg of anhydrous potassium carbonate in turn, heat the oil bath to 116°C for reflux reaction for 4h, stop heating, and react for a while. Cool for 0.5h, then add 38.3kg (266mol) of 2-Dimethylaminoethyl Chloride Hydrochloride, continue to heat to 116°C for reflux reaction for 4h, and cool to below 30°C after the reaction is complete, then add deionized water 127.0 kg stirred for 30min, left standing for 1h, separated the organic layer, dried and concentrated to obtain an oily substance, then added 169.0kg of acetone and stirred, adjusted the pH value with concentrated hydrochloric acid to 3-4, and precipitated a large number of crystals, which continued to crystallize for 12h after freezing. , centrifugal filtration and drying to obtain 53.0kg of white solid which is tetracaine hydrochloride, the yield is 85.07%, and the HPLC purity is 99.34%.
Therapeutic FunctionLocal anesthetic
General DescriptionTetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.
Biological Activitytetracaine hcl is a potent local anaesthetic and a channel function allosteric inhibitor.tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of ca2+ from sarcoplasmic reticulum. tetracaine is a potent local
Biochem/physiol ActionsBlocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.
Contact allergensAmethocaine is a local anesthetic used in dental surgery. It was reported as an agent of contact dermatitis in dentists or dental nurses and in ophthalmologists
Side effectsTetracaine hydrochloride is in the ester-type local anesthetic family of medications. It works by blocking the sending of nerve impulses. common side effects include Transient stinging, burning, and conjunctival redness, eye irritation, eye pain, ocular discomfort. Allergic reactions may uncommonly occur. Long term use is generally not recommended as it may slow healing of the eye. It is unclear if use during pregnancy is safe for the baby.

Company Profile Introduction

Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers. Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries. The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit. Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.

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