TD139 NEW
| Price | $64 | $129 | $213 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: TD139 | CAS No.: 1450824-22-2 |
| Purity: 99.66% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | TD139 |
| Description | TD139 is a small molecule inhibitor of inhaled galectin-3 (Gal-3) with potential anti-fibrotic activity, commonly used in the study of idiopathic pulmonary fibrosis. |
| In vitro | TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1]. |
| In vivo | In primary lung AECs, TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, keeping most β-catenin at the cell surface, and blocks TGF-β1–induced β-catenin phosphorylation. TD139 treatment in WT mice results in a marked reduction in lung fibrosis and β-catenin activation, along with decreased galectin-3 expression [1]. Pretreatment of WT C57BL/6 mice with TD139 attenuates liver injury, reduces infiltration of IFNγ-, IL-17-, and IL-4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages, and prevents apoptosis of liver-infiltrating MNCs [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : Insoluble Ethanol : 3 mg/mL DMSO : 55 mg/mL (84.79 mM) |
| Keywords | TD-139 | TD 139 | TD139 |
| Inhibitors Related | G3-C12 acetate(848301-94-0 free base) | Galectin-3 antagonist 2 | Thiodigalactoside | Galectin-3/galectin-8-IN-1 | Galectin-3/galectin-8-IN-2 | GB1107 | DB21, Galectin-1 Antagonist | OTX008 |
| Related Compound Libraries | 非甾體類抗炎化合物庫(kù) | 經(jīng)典已知活性庫(kù) | ReFRAME 相關(guān)化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | 抗纖維化化合物庫(kù) | NO PAINS 化合物庫(kù) | 臨床期小分子藥物庫(kù) | 已知活性化合物庫(kù) | 抗代謝疾病化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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