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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Ubiquitin>DUB inhibitors>TCID
TCID
  • TCID

TCID NEW

Price $52 $80 $178
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: TCID CAS No.: 30675-13-9
Purity: 97.16% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱TCID
描述TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
體外活性TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 14.2 mg/mL (50 mM)
關鍵字hydrolase | C-terminal | Neuronal | Deubiquitinase | transporter | ubiquitination | DUBs | inhibit | glycine | ubiquitin | UCH-L3 | TCID | UCH-L1 | GlyT2 | Inhibitor
相關產(chǎn)品P22074 | BAY 11-7082 | USP15-IN-1 | N-Ethylmaleimide | DUB-IN-1 | SJB3-019A | USP30 inhibitor 11 | Vialinin A | GRL0617 | Spautin-1 | 6-Thioguanine | USP8-IN-3
相關庫高選擇性抑制劑庫 | DNA 損傷和修復分子庫 | 經(jīng)典已知活性庫 | 泛素化化合物庫 | HIF-1化合物庫 | 藥物片段庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細胞周期化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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