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Postion:Product Catalog >TC14012 acetate
TC14012 acetate
  • TC14012 acetate

TC14012 acetate NEW

Price $77 $296 $473
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-12

Product Details

Product Name: TC14012 acetate Purity: 99.71%
Supply Ability: 10g Release date: 2024/11/12

Product Introduction

Bioactivity

名稱TC14012 acetate
描述TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
體外活性TC14012 (1 mM) inhibits more than 95% the infection of the CXCR4-expressing cells by the HXB2 (X4) or 89.6 (dual-tropic) strain. TC14012 (1 mM) does not inhibit all the infection of the CCR5-expressing cells by the SF162 (R5) or 89.6 (dualtropic) strain. TC14012 leads to erk 1/2 phosphorylation in U373 cells, which express endogenous CXCR7 but not CXCR4. CXCR7 and the CXCR7-Cter4 chimera are able to recruit arrestin upon stimulation with TC14012 whereas CXCR4 and CXCR4-Cter7 remain silent.
存儲(chǔ)條件store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
關(guān)鍵字TC-14012 acetate | TC14012 acetate | TC 14012 Acetate | TC14012 Acetate | TC-14012 Acetate
相關(guān)產(chǎn)品AZD8309 | rac-NBI-74330 | Tannic acid | Artemotil | GP 1a | CXCR2-IN-1 | Plerixafor octahydrochloride | GPR35 agonist 2 | Nicotinamide N-oxide | Plerixafor
相關(guān)庫趨化因子抑制劑庫 | 多肽分子庫 | NO PAINS 化合物庫 | 抗感染化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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