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Postion:Product Catalog >TC-MCH 7c
TC-MCH 7c
  • TC-MCH 7c

TC-MCH 7c NEW

Price $95 $289 $415
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: TC-MCH 7c CAS No.: 864756-35-4
Purity: 98.8% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱TC-MCH 7c
描述TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
體外活性In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2].
體內(nèi)活性In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度1eq. HCl : 36.8 mg/mL (90.0 mM)
DMSO : 55 mg/mL (134.65 mM), Sonication is recommended.
關(guān)鍵字TC-MCH 7c | TCMCH 7c | TC MCH 7c
相關(guān)產(chǎn)品MCH(human, mouse, rat) | MCHR1 antagonist 2 | ATC 0175 hydrochloride | SNAP 94847 | Melanin Concentrating Hormone, salmon acetate | Neuropeptide EI, rat acetate | PG 931 acetate | SNAP 94847 hydrochloride | [Ala17]-MCH acetate
相關(guān)庫經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 | 含氟化合物庫 | GPCR靶點(diǎn)分子庫 | 抗癌化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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