TC-MCH 7c NEW
Price | $95 | $289 | $415 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-15 |
Product Details
Product Name: TC-MCH 7c | CAS No.: 864756-35-4 |
Purity: 98.8% | Supply Ability: 10g |
Release date: 2024/11/15 |
Product Introduction
Bioactivity
名稱 | TC-MCH 7c |
描述 | TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM. |
體外活性 | In [Ca2+]i mobilization, TC-MCH 7c has an IC50 of 9.7 μM for MCH1R [1]. TC-MCH 7c has IC50s of 23 nM and 9.0 μM for FLIPR and hERG, respectively[2]. |
體內(nèi)活性 | In DIO mice model, TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) shows excellent body weight reduction in a dose-dependent manner [1]. TC-MCH 7c(oral; 3 to 30mg /kg) and 30mg /kg at 2, 15 and 24 h were 5.1, 1.8 and 0.7 μM, respectively[2]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | 1eq. HCl : 36.8 mg/mL (90.0 mM) DMSO : 55 mg/mL (134.65 mM), Sonication is recommended. |
關(guān)鍵字 | TC-MCH 7c | TCMCH 7c | TC MCH 7c |
相關(guān)產(chǎn)品 | MCH(human, mouse, rat) | MCHR1 antagonist 2 | ATC 0175 hydrochloride | SNAP 94847 | Melanin Concentrating Hormone, salmon acetate | Neuropeptide EI, rat acetate | PG 931 acetate | SNAP 94847 hydrochloride | [Ala17]-MCH acetate |
相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 | 含氟化合物庫 | GPCR靶點(diǎn)分子庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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