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Postion:Product Catalog >Taurochenodeoxycholic acid sodium
Taurochenodeoxycholic acid sodium
  • Taurochenodeoxycholic acid sodium

Taurochenodeoxycholic acid sodium NEW

Price $46
Package 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Taurochenodeoxycholic acid sodium CAS No.: 6009-98-9
Purity: 99.45% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameTaurochenodeoxycholic acid sodium
DescriptionTaurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties. It can increase glucose-induced insulin secretion and stimulate the electrical activity of α2-cells and enhance cytosolic Ca(2+) concentration ([Ca(2+)](c)).
In vitroExperiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively. Sodium taurochenodeoxycholate (TCDC) increased glucose-induced insulin secretion. This effect was mimicked by the FXR agonist GW4064 and suppressed by the FXR antagonist guggulsterone. TCDC and GW4064 stimulated the electrical activity of β-cells and enhanced cytosolic Ca(2+) concentration ([Ca(2+)](c)). These effects were blunted by guggulsterone. Sodium ursodeoxycholate, which has a much lower affinity to FXR than TCDC, had no effect on [Ca(2+)](c) and insulin secretion. FXR activation by TCDC is suggested to inhibit K(ATP) current. The decline in K(ATP) channel activity by TCDC was only observed in β-cells with intact metabolism and was reversed by guggulsterone. TCDC did not alter insulin secretion in islets of SUR1-KO or FXR-KO mice. TCDC did not change islet cell apoptosis.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 25 mg/mL (47.83 mM)
KeywordsmRNA | Taurochenodeoxycholic acid | acid | anti-inflammatory | JNK | regulation | PKC | 12-Deoxycholyltaurine | Inhibitor | TNF-α | immune | NR8383 | caspase-8 | Endogenous Metabolite | Taurochenodeoxycholic acid sodium | TIMP-2 | bile | caspase-3 | inhibit | Apoptosis
Inhibitors RelatedSucrose | Stavudine | Daidzein | Guanidine hydrochloride | Fumaric acid | Tributyrin | Ferulic Acid | Glycerol | Thymidine | Naringin
Related Compound LibrariesAnti-Tumor Natural Product Library | Apoptosis Compound Library | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | Anti-Fibrosis Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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