Tannic acid NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Tannic acid | CAS No.: 1401-55-4 |
| Purity: AR | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Tannic acid |
| Description | Tannic acid (Gallotannic acid) is a novel hERG channel blocker. |
| In vitro | METHODS: Rat cardiomyocytes H9C2 were treated with Tannic acid (5-50 μM) for 24 h. Cell viability was determined by CCK-8 Assay. RESULTS: Treatment of H9C2 cells with Tannic acid concentration ≥ 30 μM resulted in a significant decrease in cell viability. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 μM) for 24-48 h. Cell cycle was measured by Flow cytometry. RESULTS: Tannic acid inhibited cell viability in a dose-dependent manner at 24 h, with higher inhibition after 48 h. The IC50 values for Tannic acid were estimated to be in the range of 40-60 μM at 24 h and 20-40 μM at 48 h. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 μM) for 24-48 h. Cell cycle was measured by Flow cytometry. [2] |
| In vivo | METHODS: To investigate the effects on oxidative stress mice, Tannic acid (2.5-10 mg/kg) was administered orally to diquat-induced oxidative stress C57BL/6J mouse model once daily for ten days. RESULTS: Tannic acid pretreatment in the oxidative stress mouse model failed to alter antioxidant enzymes but modulated jejunal morphology, colon length, antioxidant pathways, and intestinal barrier in the diquat oxidative model. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (14.7 mM), Sonication is recommended. H2O : 17.24 mg/mL (10.13 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | Tannic acid | Potassium Channel | KcsA |
| Inhibitors Related | AZD8309 | rac-NBI-74330 | Delmetacin | SB225002 | CXCR2-IN-1 | LIT927 | Reparixin | JMS-17-2 | Plerixafor octahydrochloride | SX-682 | Plerixafor | CXCL-CXCR1/2-IN-1 |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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