Product Details
| Product Name:
Talquetamab |
CAS No.:
2226212-40-2 |
| Purity:
99.7% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Talquetamab |
| 描述 | Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity. |
| 體外活性 | Talquetamab, at concentrations ranging from 0.00128 to 4.0 μg/mL for 48 hours, effectively induces lysis of multiple myeloma cells. This induction is accompanied by a significant dose-dependent increase in the proportion of activated CD4+ and CD8+ T cells, as well as elevated levels of granule enzyme B and inflammatory cytokines such as IL-6, IL-8, and TNF-α [2]. |
| 體內(nèi)活性 | Talquetamab (JNJ-64407564), administered subcutaneously or intravenously at doses ranging from 0.1 to 50 μg, exhibits significant anti-tumor activity in H929 and MM mouse models [1]. |
| 存儲條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 相關(guān)產(chǎn)品 | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Octopamine hydrochloride | L-DOPA | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States