Talazoparib tosylate NEW
| Price | $44 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Talazoparib tosylate | CAS No.: 1373431-65-2 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Talazoparib tosylate |
| Description | Talazoparib tosylate (BMN 673ts) is an orally active and highly potent PARP1/2 inhibitor with antitumor activity for the study of specific breast cancers. |
| In vitro | Talazoparib tosylate had similar inhibitory effects on PARP1 and PARP2 (Ki values of 1.20 nM and 0.85 nM, respectively). Talazoparib tosylate induced the formation of an intranuclear γ-H2AX focus at concentrations as low as 100 pM. Talazoparib tosylate had no effect on PARG activity at concentrations up to 1 μM. The dissociation constant for binding of Talazoparib tosylate to PARP1 was 0.29 nM. Talazoparib tosylate selectively targets tumor cells with defects in the BRCA1, BRCA2 or PTEN genes with 20- to 200-fold greater potency than existing PARP1/2 inhibitors. Talazoparib tosylate specifically targets tumor cells with defects in homologous recombination genes, and tumor models with defects in BRCA1 or BRCA2 defective tumor models are extremely sensitive to Talazoparib tosylate. [1] |
| In vivo | Talazoparib tosylate has high oral bioavailability, with absolute bioavailability exceeding 40% when administered orally in rats using carboxymethylcellulose as the vehicle. Talazoparib tosylate has significant antitumor effects when administered orally; Talazoparib tosylate exhibits high potency sensitivity in transplanted tumors with impaired DNA repair due to BRCA mutations or PTEN defects when administered at well-tolerated doses in mice. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 0.1 mg/mL (insoluble) DMSO : 100 mg/mL (180.98 mM), Sonication is recommended. |
| Inhibitors Related | 4'-Methoxychalcone | Niraparib tosylate monohyrate | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | 3-Methoxybenzamide | NU1025 | Olaparib | Benzamide | Picolinamide | OUL35 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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