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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>Adrenergic Receptor agonists> Synephrine Hydrochloride
 Synephrine Hydrochloride
  •  Synephrine Hydrochloride
  •  Synephrine Hydrochloride
  •  Synephrine Hydrochloride
  •  Synephrine Hydrochloride
  •  Synephrine Hydrochloride

Synephrine Hydrochloride NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 10000kg
Update Time: 2024-05-08

Product Details

Product Name: Synephrine Hydrochloride CAS No.: 5985-28-4
EC-No.: 227-804-6 Min. Order: 1kg
Purity: 99% Supply Ability: 10000kg
Release date: 2024/05/08

Factory Provide CAS 5985-28-4 Synephrine HCl Powder Synephrine Hydrochloride


Article illustration

Introduction

Product Name :  Synephrine Hydrochloride

Other name:1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride;4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride;Synephrine hcl

CAS No.: 5985-28-4

MF:C9H14ClNO2

MW:208.12

Specification:99%

Appearance: White to off white powder 

Melting Point :147-150°CPredicted)

Storage :Keep in dark place,Inert atmosphere,Room temperature


Synephrine Hydrochloride is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). Synephrine Hydrochloride is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). Synephrine Hydrochloride induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (ynephrine Hydrochloride (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Product Name:Synephrine Hydrochloride
Country of Origin:ChinaCAS No.5985-28-4
ITEMSPECIFICATIONMETHOD
PhysicalAppearanceWhite to off-White crystalline powderVisual
IdentificationIR spectrumHPLC
Particle size98% pass 80meshSieve
Loss on drying≤0.5%2g/105oC/5hrs
Residue on ignition≤0.5%2g/800oC/5hrs
ChemicalHeavy metals≤10ppmColorimetric method
Arsenic (As)≤2ppmAtomic Absorption
Lead (Pb)≤2ppmAtomic Absorption
Cadmium (Cd)≤1ppmAtomic Absorption
Mercury (Hg)≤1ppmAtomic Absorption
AssaySynephrine Hydrochloride≥99%HPLC
MicrobialTotal Plate Count≤1000CFU/gChP
Yeast & Mold≤100CFU/gChP
E.ColiNegativeChP
SalmonellaNegativeChP
StaphylococcusNegativeChP
ElsePackingPack in paper-drums and two food grade poly bags inside. Net weight: 25kg/drum
Storage conditionStore in a well closed place with constant low temperature and no direct sun light
Shelf lifeTwo years when properly stored.


Function 

1. Anti-oxidant, Reduce environmental pollution damage to the body;
2. Synephrine HCL can consolidate connective tissue; strengthen skin, bones, teeth and muscles;
3. Synephrine HCL can promote collagen synthesis, help wound healing;
4. Involved in cholesterol metabolism and help break down fat;
5. Synephrine HCL can accelerate iron and calcium absorption, prevent scurvy.

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Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR ChinaChina
  • Since: 2019-05-23
  • Address: No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New C
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