Synephrine Hydrochloride NEW
Price | Get Latest Price |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 10000kg |
Update Time: | 2024-05-08 |
Product Details
Product Name: Synephrine Hydrochloride | CAS No.: 5985-28-4 |
EC-No.: 227-804-6 | Min. Order: 1kg |
Purity: 99% | Supply Ability: 10000kg |
Release date: 2024/05/08 |
Factory Provide CAS 5985-28-4 Synephrine HCl Powder Synephrine Hydrochloride
Introduction
Product Name : Synephrine Hydrochloride
Other name:1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride;4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride;Synephrine hcl
CAS No.: 5985-28-4
MF:C9H14ClNO2
MW:208.12
Specification:99%
Appearance: White to off white powder
Melting Point :147-150°CPredicted)
Storage :Keep in dark place,Inert atmosphere,Room temperature
Synephrine Hydrochloride is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). Synephrine Hydrochloride is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). Synephrine Hydrochloride induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (ynephrine Hydrochloride (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
Product Name: | Synephrine Hydrochloride | ||
Country of Origin: | China | CAS No. | 5985-28-4 |
ITEM | SPECIFICATION | METHOD | |
Physical | Appearance | White to off-White crystalline powder | Visual |
Identification | IR spectrum | HPLC | |
Particle size | 98% pass 80mesh | Sieve | |
Loss on drying | ≤0.5% | 2g/105oC/5hrs | |
Residue on ignition | ≤0.5% | 2g/800oC/5hrs | |
Chemical | Heavy metals | ≤10ppm | Colorimetric method |
Arsenic (As) | ≤2ppm | Atomic Absorption | |
Lead (Pb) | ≤2ppm | Atomic Absorption | |
Cadmium (Cd) | ≤1ppm | Atomic Absorption | |
Mercury (Hg) | ≤1ppm | Atomic Absorption | |
Assay | Synephrine Hydrochloride | ≥99% | HPLC |
Microbial | Total Plate Count | ≤1000CFU/g | ChP |
Yeast & Mold | ≤100CFU/g | ChP | |
E.Coli | Negative | ChP | |
Salmonella | Negative | ChP | |
Staphylococcus | Negative | ChP | |
Else | Packing | Pack in paper-drums and two food grade poly bags inside. Net weight: 25kg/drum | |
Storage condition | Store in a well closed place with constant low temperature and no direct sun light | ||
Shelf life | Two years when properly stored. |
Function
1. Anti-oxidant, Reduce environmental pollution damage to the body;
2. Synephrine HCL can consolidate connective tissue; strengthen skin, bones, teeth and muscles;
3. Synephrine HCL can promote collagen synthesis, help wound healing;
4. Involved in cholesterol metabolism and help break down fat;
5. Synephrine HCL can accelerate iron and calcium absorption, prevent scurvy.
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