Suberoyl bis-hydroxamic acid NEW
Price | $29 |
Package | 100mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-18 |
Product Details
Product Name: Suberoyl bis-hydroxamic acid | CAS No.: 38937-66-5 |
Supply Ability: 10g | Release date: 2024/11/18 |
Product Introduction
Bioactivity
名稱 | Suberoyl bis-hydroxamic acid |
描述 | Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones. |
體外活性 | In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | H2O : 8.16 mg/mL (40 mM), Sonication is recommended. DMSO : 49 mg/mL (239.93 mM), Sonication is recommended. |
關(guān)鍵字 | MTC | inhibit | Histone deacetylases | Malignant | carcinoma | neoplastic disease | Suberoyl bis-hydroxamic acid | neuroendocrine malignancy | neoplasia | mesothelioma | Apoptosis | Suberoyl bishydroxamic acid | thyroid | Inhibitor | Medullary | Suberoyl bis hydroxamic acid | HDAC |
相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Tributyrin | Curcumin |
相關(guān)庫 | 細(xì)胞凋亡化合物庫 | 組蛋白修飾化合物庫 | 細(xì)胞重編程化合物庫 | 經(jīng)典已知活性庫 | 染色質(zhì)修飾分子庫 | 抑制劑庫 | 線粒體靶向庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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