SSD114 HCl NEW
| Price | $32 | $80 | $122 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SSD114 HCl | CAS No.: 2319790-02-6 |
| Purity: 99.03% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SSD114 HCl |
| Description | SSD114 is a novel GABAB receptor positive allosteric modulator. |
| In vitro | In conditions containing 10 μM GABA, 25 μM SSD114 hydrochloride significantly increased the level of [35S]GTPγS activation induced by GABA alone to approximately 170% of basal levels.SSD114 hydrochloride (15 or 30 μM) caused a shift in the GABA concentration-response curve to the left and at the highest concentration slightly increased the maximal stimulatory effect of GABA. In the co-presence of 15 and 30 μM SSD114 hydrochloride, the EC50 of GABA was reduced by 2-fold and 2.5-fold, respectively, while the maximal stimulatory effect (Emax) was enhanced only at the 30 μM concentration to 161 ± 5.09% of the basal value [1]. |
| In vivo | SSD114 hydrochloride pretreatment significantly shortened the onset time of the loss-of-orientation reflex (LORR) [F(5,30)=4.55, P<0.005]. Follow-up analyses showed that the onset time of LORR was significantly shorter in the group of mice that received pretreatment at doses equal to or higher than 10 mg/kg SSD114 hydrochloride compared to the control group. In addition, SSD114 hydrochloride pretreatment prolonged the duration of LORR [F(5,30)=4.81, P<0.005]. Follow-up analysis indicated that the LORR duration was significantly prolonged in the group of mice receiving 10 and 100 mg/kg SSD114 hydrochloride pretreatment compared to the control group [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (116.03 mM) |
| Keywords | SSD-114 hydrochloride | SSD114 Hydrochloride | SSD-114 Hydrochloride | SSD 114 Hydrochloride |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | β-Alanine | Penicillin G sodium salt | Halothane | Valproic Acid | Chlorothymol | Piperazine citrate | Riluzole | Gabapentin | Nikethamide | (-)-α-Pinene |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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