(S,R,S)-AHPC hydrochloride NEW
| Price | $48 | $72 | $247 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: (S,R,S)-AHPC hydrochloride | CAS No.: 1448189-80-7 |
| Purity: 99.29% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | (S,R,S)-AHPC hydrochloride |
| 描述 | (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). |
| 體外活性 | Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used |
| 存儲(chǔ)條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mM |
| 關(guān)鍵字 | (S,R,S) AHPC hydrochloride | VHL Ligand 1 Hydrochloride | VH032-NH2 | (S,R,S)AHPC hydrochloride | inhibit | (S,R,S)-AHPC | VHL ligand 1 | Ligands for E3 Ligase | Protein degrader 1 Hydrochloride | VHL ligand-1 | ULM1 | E3 ligase-recruiting Moiety | VHL ligand1 | ULM 1 | Inhibitor | AHPC Hydrochloride |
| 相關(guān)產(chǎn)品 | Lenalidomide-Br | (S,R,S)-AHPC | Thalidomide | (S,R,S)-AHPC | Pomalidomide | Lenalidomide | Thalidomide-5-OH | 5-Aminothalidomide | Thalidomide 5-fluoride | Thalidomide-4-OH |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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