Product Details
Product Name:
SR11237 |
CAS No.:
146670-40-8 |
Purity:
98.54% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | SR11237 |
Description | SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
In vitro | SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2]. |
In vivo | In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 4 mg/mL (10.51 mM), Sonication and heating to 60℃ are recommended.
|
Keywords | Retinoid X receptors | bone | BMS 649 | transactivate | BMS649 | Retinoic acid receptors | reporter | ossification | RAR/RXR | inhibit | Inhibitor | RXR/RXR | BMS-649 | SR11237 | homodimers | SR-11237 | gene |
Inhibitors Related | Bigelovin | K-80003 | Latanoprost | K-8012 | PA452 |
Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |