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Postion:Product Catalog >SR11237
SR11237
  • SR11237

SR11237 NEW

Price $64 $156 $239
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: SR11237 CAS No.: 146670-40-8
Purity: 98.54% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameSR11237
DescriptionSR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
In vitroSR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2].
In vivoIn Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 4 mg/mL (10.51 mM), Sonication and heating to 60℃ are recommended.
KeywordsRetinoid X receptors | bone | BMS 649 | transactivate | BMS649 | Retinoic acid receptors | reporter | ossification | RAR/RXR | inhibit | Inhibitor | RXR/RXR | BMS-649 | SR11237 | homodimers | SR-11237 | gene
Inhibitors RelatedBigelovin | K-80003 | Latanoprost | K-8012 | PA452
Related Compound LibrariesNuclear Receptor Compound Library | Bioactive Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library | Neuronal Differentiation Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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