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Postion:Product Catalog >API>Urinary System Drugs>Diuretics Drugs>Spironolactone
Spironolactone
  • Spironolactone
  • Spironolactone
  • Spironolactone
  • Spironolactone
  • Spironolactone

Spironolactone

Price Get Latest Price
Package 1kg 25kg 50kg
Min. Order: 1kg
Supply Ability: 50tons
Update Time: 2023-09-14

Product Details

Product Name: Spironolactone CAS No.: 52-01-7
EC-No.: 200-133-6 Min. Order: 1kg
Purity: 99% Supply Ability: 50tons
Release date: 2023/09/14

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Product Description

CAS No.: 52-01-7
Chemical Name: Spironolactone
Molecular Formula: C24H32O4S
Molecular Weight:  416.58
EINECS: 200-133-6

Melting point207-208 °C (lit.)
alpha-37 o (c=1, CHCl3)
Boiling point504.87°C (rough estimate)
Density1.1061 (rough estimate)
refractive index-36 ° (C=1, CHCl3)
storage temp.2-8°C
solubilityPractically insoluble in water, soluble in ethanol (96 per cent).
formPowder
colorWhite to yellow-white
Water Solubilitypractically insoluble
Merck14,8760
BCS Class2,4,3
LogP2.780

Definition & Usage

Definition

A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Uses

It can be used as a kind of inefficient diuretic drugs.
It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia.
The active metabolite of lactone (spironolactone); It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.

Spironolactone, an aldosterone-, and competitive androgen-receptor-antagonist and 5-alpharductase- inhibitor, indicated for the treatment of androgen dependent hirsutism, ideally in doses of 50 to 200 mg per day accompanying the intake of oral contraceptives with the same seven day break in between. Side effects concerning the length of the menstrual cycle, the increase of blood pressure or potassium levels may occur. Spironolactone is the number one drug in the treatment of hirsutism in the US (Farquhar et al., 2003). In other countries the prescription of spironolactone for the treatment of hirsutism may be off-label.

It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia

diuretic, aldosterone antagonist

Article illustration

My email    admin06@hsnm.com.cn



Company Profile Introduction

Wuhan Hansheng New Material Technology Co.Ltd founded in 2022. our company mainly supply steroid raw powders,sarms raw powders,fat burner raw powders,peptides, food addtives, API raws,Cosmetics raw powders.veterinary raw powders. Our company is a professional manufacturer leading factory in China in pharmaceutical area for many years, our products have exported to USA,Greece, Spain, UK, Germany, Australia and other countries, and we have got very good feedback from our customers, we had established a long term friendly relations with our customers all over the world, and in some area like Europe and North America, we have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. High quality, best price, first-class service, high successful delivery rate, we have stock, so we can delivery quickly at the very day when payment is arrived.

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