Sophocarpine NEW
| Price | $45 | $72 | $145 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Sophocarpine | CAS No.: 6483-15-4 |
| Purity: 98.67% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Sophocarpine |
| Description | Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
| In vitro | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
| In vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 49 mg/mL (198.9 mM) H2O : 5 mg/mL (20.30 mM) DMSO : 49 mg/mL (198.9 mM) |
| Keywords | Apoptosis | Influenza Virus | PI3K | Phosphoinositide 3-kinase | Inhibitor | Autophagy | PKB | Akt | Protein kinase B | inhibit | Sophocarpine |
| Inhibitors Related | TBHQ | Bismuth Subsalicylate | Ibuprofen | Acetaminophen | Hydroxychloroquine | Diclofenac sodium | Glucosamine | Diclofenac Potassium | Lidocaine hydrochloride | Indole-3-carbinol | Paradol | Diallyl disulfide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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