SMN-C3 NEW
| Price | $179 | $455 | $672 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SMN-C3 | CAS No.: 1449597-34-5 |
| Purity: 99.31% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SMN-C3 |
| Description | SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA). |
| In vivo | At P16, vehicle-treated D7 mice were significantly smaller and dying compared to heterozygous control littermates. In contrast, D7 mice treated with high doses of SMN-C3 exhibited phenotypes similar to the heterozygous controls. SMN-C3 treatment in D7 mice induces dose-dependent body weight gain, with some achieving ~80% of heterozygous control weight. SMN-C3 also normalizes D7 motor behavior, allowing rapid self-righting and comparable locomotor activity to heterozygous controls. Importantly, vehicle-treated mice die within 3 weeks post-birth (median survival of 18 days), whereas SMN-C3 extends survival dose-dependently, with a median of 28 days at low dose (0.3 mg/kg/day) and ~90% survival beyond P65 in the higher doses (1 and 3 mg/kg/day) [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.0 mg/mL (4.8 mM), Sonication and heating to 60℃ are recommended. |
| Keywords | SMN-C3 |
| Inhibitors Related | Rifampicin | 5-Fluorouracil | Ribavirin | Guanidine hydrochloride | 2,4-D | Resveratrol | Trimethoprim | Azelaic acid | Acyclovir | Thymidine | Temozolomide | Folic acid |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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