SLLN-15 NEW
| Price | $2140 | $2785 | $3520 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SLLN-15 | CAS No.: 2403650-93-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SLLN-15 |
| Description | SLLN-15 is an orally active, selective, and potent enhancer of autophagy, activating cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC) [1]. |
| In vitro | Treatment with SLLN-15 at concentrations of 0, 1, 5, 10, and 25 μM for 24 hours significantly decreases the viability of breast cancer cells in a dose-dependent manner, demonstrating its potency against these cells [1]. Similarly, SLLN-15 administered at 100 nM and 1000 nM for 7 days effectively inhibits the colony formation abilities across various breast cancer cell lines, including TNBC (triple-negative breast cancer) lines like MDA-MB-231 and BT-20, without discrimination [1]. SLLN-15 exercises its anti-proliferative effects on TNBC cell lines MDA-MB-231 and BT-20, predominantly through the induction of autophagy and autophagic flux. This action corresponds with a specific inhibition of the AKT-MTOR signaling pathway, further establishing its targeted mechanism in reducing cell viability and proliferation in these cancer cells. |
| In vivo | SLLN-15 (30mg/kg, PO, 3 times a week) effectively suppresses triple-negative breast cancer (TNBC) growth and hinders metastasis in animal models, demonstrating significant anti-cancer and anti-metastatic properties. In BALB/c or SCID mice implanted with 1 X 10^6 mouse 4T1 or human MDA-MB-231 cells [1], SLLN-15 markedly slowed tumor growth and reduced lung metastases compared to controls [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | SLLN 15 | SLLN15 | SLLN-15 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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