Product Details
Product Name:
SLF1081851 |
CAS No.:
2763730-97-6 |
Purity:
98.57% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | SLF1081851 |
Description | SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM. |
In vitro | SLF1081851 (compound 16d) (0-5 μM; 18-20 h) inhibits S1P release with an IC50 value of 1.93 μM in Hela cells[1]. SLF1081851 (0-30 μM; 20 min) inhibits mSphK1 (recombinant mouse SphK) (10 μM) and mSphK2 (5 μM) in a dose-dependent manner and suggests at least 15-fold selectivity (SphK1 IC50≥30 μM; SphK2 IC50≈30 μM)[1]. |
In vivo | SLF1081851 (20 mg/kg; i.p., 4 h postdose) significantly inhibits circulating lymphocytes and plasma S1P. SLF1081851 recapitulates the genetic phenotype of Spns2 null mice[1]. |
Storage | Shipping with blue ice. |
Solubility Information | Ethanol : 9.0 mg/mL (26.2 mM), Sonication is recommended.
|
Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | Tyloxapol | ASP-4058 | Ki16198 | CYM50260 | Siponimod | Fingolimod | S1PR1 modulator 1 | Ozanimod | CYM50308 | Ki16425 |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |