SK609 HCl NEW
| Price | $80 | $196 | $288 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: SK609 HCl | CAS No.: 1092797-77-7 |
| Purity: 99.02% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | SK609 HCl |
| 描述 | SK609 HCl (SK609 hydrochloride) is a dopamine D3 receptor (D3R) selective agonist that inhibits norepinephrine transporter proteins and can be used to study Parkinson's disease and cognitive disorders. |
| 體外活性 | SK609 activated Gi/o proteins and downstream ERK1/2 signaling, but had no effect on D2R/ERK1/2. The EC50 values of SK609 for [35S]GTPγS binding, ERK1/2 phosphorylation, and β-trap proteins were 1.1±0.2 μM, 50.2±5.9 nM, and 14.4±2.7 μM, respectively; the EC50 value of SK609 at D3R was 1109±273 nM in a competitive inhibition affinity assay [1]. In the competitive inhibition affinity assay of SK609 against D3R, the EC50 value of SK609 at D3R was 1109±273 nM [1]. |
| 體內(nèi)活性 | Safety toxicology studies in rats have shown that the maximum tolerated dose of SK609 is 30 mg/kg, and all doses used in this study were at SK609 [1]; in a PK study in Crab Monkeys, oral administration of SK609 (P.O.; 0.5, 2, and 4 mg/kg) was associated with mean Cmax values at 4.1, 6.4, and 5.0 hours post-dose (Tmax) were 13.7, 69.3, and 218 ng/mL, respectively, with corresponding AUC (0-t) values of 171, 904, and 2938 h.ng/mL; the mean terminal half-life of SK609 in plasma after intravenous administration (2 mg /kg) was 7.9 h. SK609 (i.p.; 2, 4, 6, 8, 10, and 20 mg/kg) was shown to be significant in a rat model of Parkinsonism. Parkinson's model significantly improved and normalized bilateral asymmetry in hemiplegic rats [3]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 關(guān)鍵字 | SK609 HCl |
| 相關(guān)產(chǎn)品 | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Octopamine hydrochloride | Octodrine | Citicoline | Amitriptyline hydrochloride | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 | GPCR靶點(diǎn)分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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