Sivelestat sodium tetrahydrate NEW
Price | $42 | $67 | $129 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-11 |
Product Details
Product Name: Sivelestat sodium tetrahydrate | CAS No.: 201677-61-4 |
Purity: 99.64% | Supply Ability: 10g |
Release date: 2024/11/11 |
Product Introduction
Bioactivity
名稱 | Sivelestat sodium tetrahydrate |
描述 | Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. |
體外活性 | Sivelestat (ONO-5046) is not an inhibitor of trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin, or cathepsin G, even at concentrations up to 100 μM[1]. However, it effectively inhibits neutrophil elastase across various species, demonstrating IC50 values of 44 nM (human), 36 nM (rabbit), 19 nM (rat), 37 nM (hamster), and 49 nM (mouse), showcasing its specificity and potential for therapeutic applications[1]. |
體內(nèi)活性 | Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamsters (ID50 = 82 pg/kg) and increases skin capillary permeability in guinea pigs (ID50 = 9.6 mg/kg) via intravenous administration, both induced by human neutrophil elastase[1]. Additionally, Sivelestat (10 mg/kg, tail vein infusion) ameliorates lung injury after hemorrhagic shock in rats[2], and prevents ischemia-reperfusion injury in the rat bladder (15, 60 mg/kg, ip)[3]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 225 mg/mL (425.7 mM), Sonication is recommended. |
關(guān)鍵字 | ONO-5046 sodium Tetrahydrate | Elaspol sodium | ONO5046 sodium | Sivelestat sodium | ONO5046 sodium Tetrahydrate | ONO-5046 sodium | Elaspol sodium Tetrahydrate | Sivelestat sodium Tetrahydrate |
相關(guān)產(chǎn)品 | PMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | Leupeptin Hemisulfate | 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one | Ceritinib | Aprotinin | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
相關(guān)庫 | FDA上市及藥典收錄分子庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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