Product Details
| Product Name:
Sincalide ammonium |
CAS No.:
70706-98-8 |
| Purity:
98.46% |
Supply Ability:
10g |
| Release date:
2025/05/27 |
Product Introduction
Bioactivity
| Name | Sincalide ammonium |
| Description | Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography. |
| In vitro | Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, functions as a novel cardiovascular hormone with a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. It also exhibits a positive role in combating inflammation, apoptosis, and collagen deposition. In the context of H9c2 cardiomyoblasts, CCK‐8 (ammonium) protects cells from Ang II-induced apoptosis, partly through the activation of the CCK1 receptor and the phosphatidylinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway[4]. |
| In vivo | In a rat model of myocardial infarction (MI), Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, alleviates fibrosis in the noninfarcted regions. Furthermore, it delays left ventricular remodeling and the progression of heart failure in the MI rat model[3]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 30 mg/mL (25.86 mM), Sonication is recommended.
|
| Keywords | Sincalide ammonium | CCK |
| Inhibitors Related | PHA-767491 | GV-150013X | (Iso)-FK-480 | Itriglumide | GV150013 | XL413 hydrochloride | Proglumide | Lintitript | N-Cbz-DL-tryptophan | A-65186 | Pranazepide | Spiroglumide |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Membrane Protein-targeted Compound Library | Peptide Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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$70.00/1kg |
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American HealthyMorph LLC
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