Sertraline hydrochloride NEW
| Price | $47 | $57 | $105 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Sertraline hydrochloride | CAS No.: 79559-97-0 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Sertraline hydrochloride |
| Description | Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
| In vitro | Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase. |
| In vivo | Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (175.08 mM), Sonication is recommended. |
| Keywords | SSRI | SLC6A4 | Sertraline Hydrochloride | Sertraline hydrochloride | Sertraline | SERT | SerotoninTransporter | Serotonin Transporter | obsessive | Inhibitor | inhibit | disorder | Antidepressant | 5-HTT | 5HTReceptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | D-Menthol | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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