SB-747651A Dihydrochloride NEW
| Price | $67 | $157 | $231 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SB-747651A Dihydrochloride | CAS No.: 1781882-72-1 |
| Purity: 97.02% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SB-747651A Dihydrochloride |
| Description | SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibits PRK2, RSK1, p70S6K, and ROCK-II, showcasing its potential in inflammation research [1]. |
| In vitro | SB-747651A dihydrochloride (5 μM; neutrophils) modulates neutrophil behavior in response to the CXCL2 chemotactic gradient by influencing CXCL2-induced intraluminal crawling in a Mac-1-dependent manner, obstructing the movement of adherent neutrophils to optimal emigration sites. It significantly prolongs the transmigration and detachment times of neutrophils, affecting their transendothelial migration. Additionally, it slows the migration velocity of extravascular chemotaxing neutrophils without altering their directionality towards CXCL2 signals. |
| In vivo | SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride significantly increases neutrophil adhesion between 3.5 and 4.5 hours after CXCL2 stimulation [3]. Additionally, the same compound administered intraperitoneally (i.p.) at the same dosage enhances neutrophil extravasation by augmenting neutrophil emigration at the 3 and 4-hour marks in a mouse peritonitis model of acute inflammation [3]. Experiments were conducted on male C57BL/6N mice aged 8 to 16 weeks, confirming that a 3 mg/kg intrascrotal injection results in heightened neutrophil adhesion following CXCL2 stimulation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (120.39 mM) |
| Keywords | SB747651A Dihydrochloride | SB 747651A Dihydrochloride | SB-747651A | SB-747651A Dihydrochloride |
| Inhibitors Related | GSK180736A | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | Y-27632 | ROCK-IN-5 | Thiazovivin |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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