SAR7334 hydrochloride NEW
| Price | $46 | $113 | $158 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SAR7334 hydrochloride | CAS No.: 1333207-63-8 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SAR7334 hydrochloride |
| Description | SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel. |
| In vitro | SAR7334 inhibits TRPC6, TRPC3, and TRPC7-mediated Ca2+ influx into cells (IC50s of 9.5, 282, and 226 nM, respectively) [1][2][3], while TRPC4 and TRPC5-mediated Ca2+ entry remains unaffected. At 1 μM, SAR7334 significantly blocks Ang II-evoked calcium influx in podocytes [1]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM, and at 100 nM, it substantially reduces TRPC6 currents [3]. |
| In vivo | In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (226.87 mM), Sonication is recommended. |
| Keywords | SAR 7334 Hydrochloride | SAR7334 Hydrochloride | SAR7334 hydrochloride | SAR-7334 Hydrochloride | SAR-7334 hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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