Product Details
| Product Name:
Saponarin |
CAS No.:
20310-89-8 |
| Purity:
98.84% |
Supply Ability:
10g |
| Release date:
2025/06/12 |
Product Introduction
Bioactivity
| Name | Saponarin |
| Description | Saponarin (Petrocomoside) shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. |
| In vitro | In freshly isolated rat hepatocytes, paracetamol (100 μ mol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60-0.006 μ g/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of Saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with Saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of Saponarin was similar to the activity of positive control silymarin[1]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 90 mg/mL (151.4 mM), Sonication is recommended.
|
| Keywords | Saponarin | P450 | NF-κB | NFκB | NF-kB | NFkB | ERK |
| Inhibitors Related | Tebuconazole | TBHQ | Diethylmaleate | Glucosamine | Lidocaine hydrochloride | Methyl cinnamate | Naringin | Metformin hydrochloride | Naringenin | Indole-3-carbinol | Diallyl disulfide | Chitosan oligosaccharide |
| Related Compound Libraries | Rare Natural Product Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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