Sanggenon C NEW
| Price | $97 | $247 | $368 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Sanggenon C | CAS No.: 80651-76-9 |
| Purity: 98.49% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Sanggenon C |
| 描述 | Sanggenon C is a flavanone Diels-Alder adduct compound isolated from the root bark of Morus alba. Sanggenon C can inhibit NF-κB activity, inhibit the expression of inducible nitric oxide synthase in RAW264.7 cells, and inhibit tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression; Sanggenon C also has antioxidant and anti-inflammatory effects, and also has the effect of inhibiting pancreatic lipase. [1,2] |
| 體外活性 | METHODS: Appropriate concentrations of Sanggenon C (10 and 20 μM) were administered to U-87MG and LN-229, as well as dimethyl sulfoxide (DMSO) as a control, for 48 hours. Cell viability was determined by MTT assay. RESULTS Sanggenon C inhibited the cell proliferation of GBM cell lines U-87 MG and LN-229 in a concentration-dependent manner.[1] METHODS: U-87 MG and LN-229 cells were treated with Sanggenon C (10 μM), cell apoptosis was detected by flow cytometry, and the expression levels of related proteins were analyzed by Western blot. RESULTS Silencing of DAPK1 reduced Sanggenon C-induced cell apoptosis. Western blot analysis further showed that in GBM cells treated with Sanggenon C, the protein levels of C-PARP and C-Caspase3 were reduced by silencing DAPK1. [1] METHODS: Human colon cancer cell line (HT-29) was treated with Sanggenon C (0, 5, 10, 20, 40 and 80 μM) for 0, 12, 24, 48 or 72 h. As a measure of intracellular ROS and ATP, the production of NO in cells was measured by the Griess method according to the instructions of the NO detection kit. RESULTS Sanggenon C can increase the level of intracellular ROS in human colon cancer cells, and this accumulation is enhanced when the dose is increased; Sanggenon C can interfere with the level of intracellular ROS; Sanggenon C can interfere with and increase the levels of intracellular Ca2+ and ATP, both in a time-dependent manner, and this accumulation is enhanced when the dose is increased; Sanggenon C can significantly interfere with and inhibit the production of NO in a dose- and time-dependent manner. [2] |
| 體內(nèi)活性 | METHODS: Mice were intraperitoneally injected with Sanggennaon C (10 mg, 20 mg/kg/day) for 3 weeks. Four weeks after surgery, the hearts, lungs, and tibiae of the mice were dissected and weighed or measured, and the heart weight (HW)/body weight (BW) (mg/g), HW/tibia length (TL) (mg/mm), and lung weight (LW)/BW (mg/g) ratios were compared among the different groups. RESULTS Sanggennaon C treatment prevented the development of ventricular dysfunction, such as decreased left ventricular end-diastolic diameter, left ventricular end-systolic diameter, and increased LVFS and LVEF; Sanggennaon C-treated mice showed attenuated cardiac hypertrophy, such as decreased CSA, and reduced HW/BW and HW/TL ratios. [2] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 7.09 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | Inhibitor | Nuclear factor-kappaB | Sanggenon C | NF-κB | Nuclear factor-κB | inhibit |
| 相關(guān)產(chǎn)品 | Sodium Houttuyfonate | Zingerone | Lidocaine | α-Lipoic Acid | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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