Product Details
| Product Name:
Sal003 |
CAS No.:
1164470-53-4 |
| Purity:
99.77% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Sal003 |
| Description | Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase. |
| Kinase Assay | Catalytic assay: MEK5 protein isolated from the baculovirus expression system is used to measure kinase activity utilizing PKLight ATP Detection Reagent. The assay is performed using 15 nM GST-MEK5 and 0.75 μM ATP in assay buffer consisting of 25 mM Hepes, pH 7.5, 10 mM MgCl2, 50 mM KCl, 0.2% BSA, 0.01% CHAPS, 100 μM Na3VO4, 0.5 mM DTT and 1% DMSO in the presence of varying concentrations of BIX02189. The kinase reaction mixture is incubated for 90 minutes at room temperature followed by addition of 10 μL of ATP detection reagent for 15 minutes. The relative light unit (RLU) signal is measured and the RLU signals are converted to percent of control (POC) values for the determination of IC50 value. |
| In vitro | In mouse embryonic fibroblasts, Sal003 induced depolymerization of polysaccharides by increasing the phosphorylation of eIF2a. Sal003 increased eIF2a phosphorylation by blocking eIF2a phosphodiesterase activity, and Sal003 enhanced the apoptotic signaling pathway induced by cytotoxicity by induced phosphorylation of eIF2α. |
| In vivo | In mouse embryonic fibroblasts, Sal003 induced depolymerization of polysaccharides by increasing the phosphorylation of eIF2a. Sal003 increased eIF2a phosphorylation by blocking eIF2a phosphodiesterase activity, and Sal003 enhanced the apoptotic signaling pathway induced by cytotoxicity by induced phosphorylation of eIF2α. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 46.3 mg/mL (100 mM)
|
| Keywords | Sal-003 | Sal 003 | Sal003 | Apoptosis | Inhibitor | inhibit | Phosphatase |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Stearic acid |
| Related Compound Libraries | Osteogenesis Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Kinase Inhibitor Library | Inhibitor Library | Lipid Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2019-12-17 |
United States