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Postion:Product Catalog >SAK3
SAK3
  • SAK3

SAK3 NEW

Price $129 $325 $483
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-20

Product Details

Product Name: SAK3 CAS No.: 1256269-87-0
Purity: 99.55% Supply Ability: 10g
Release date: 2024/11/20

Product Introduction

Bioactivity

NameSAK3
DescriptionSAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective against scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells.SAK3 is used for the study of memory deficits and Alzheimer's disease. SAK3 can be used to study memory deficits and Alzheimer's disease.
In vitroIn Neuro2A cells overexpressing Cav3.1 or Cav3.3, SAK3 (0.1 nM; 270 s) rapidly increases Ca2+ currents[2].
In vivoIn Cav3.1 knockout (KO) mice animal model, SAK3 (0.5 mg/kg; administered p.o.) significantly increased acetylcholine (ACh) release in the CA1 region, peaking at 20 minutes after oral administration[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
KeywordsSAK3
Inhibitors RelatedAdiphenine hydrochloride | L-Ascorbic acid | Ethyl cinnamate | 1-Octanol
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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