SAHA-OH NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SAHA-OH | CAS No.: 2857098-30-5 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SAHA-OH |
| Description | SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1]. |
| In vitro | SAHA-OH, at concentrations ranging from 0.67 to 10.76 μM over a period of 51 hours, demonstrates inhibitory effects on bone marrow macrophages [1]. When applied to bone marrow-derived macrophages (BMM?s) at 0.01 μM for 3 hours, SAHA-OH significantly reduces the secretion of cytokines such as IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2), and GROα (CXCL1) [1]. Additionally, a 10 μM SAHA-OH treatment for either 4 or 9 hours results in increased acetylation of cytoplasmic α-tubulin and nuclear histone H3 [1]. At dosages up to 30 μM, a 3-hour treatment with SAHA-OH effectively decreases apoptosis in macrophages and reduces death in B cells [1]. |
| In vivo | SAHA-OH, administered through intraperitoneal injection at a dose of 50 mg/kg in a single dose, mitigates splenic damage and diminishes the levels of proinflammatory cytokines in plasma in a mouse model of LPS-induced endotoxemia [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Vorinostat | Acefylline | Curcumin | Valproic Acid | 4-Phenylbutyric acid | Theophylline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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