S1R agonist 2 hydrochloride NEW
Price | $97 |
Package | 2mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: S1R agonist 2 hydrochloride | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | S1R agonist 2 hydrochloride |
Description | Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
In vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly enhances NGF-induced neurite outgrowth in a dose-dependent manner; at 1 μM over 24 hours, it markedly inhibits Rotenone-induced cellular damage in SHSY5Y cells. Additionally, it offers neuroprotection against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours. This compound exhibits no cytotoxicity in A549, LoVo, and Panc-1 cells at varying concentrations (0-10 μM) and durations (24-72 h) [1]. |
In vivo | Compound 8b (S1R agonist 2; 0.1-50 μM; 120 h) hydrochloride at a concentration of 10 μM does not induce embryonic mortality (100% survival of embryos), yet at the highest dosage (50 μM), it induces death in all embryos [1]. |
Storage | Shipping with blue ice. |
Inhibitors Related | KB-5492 free base | Cutamesine dihydrochloride | Blarcamesine hydrochloride | Amitriptyline hydrochloride | S1R agonist 2 | Ditolylguanidine | Sigma-1 receptor antagonist 1 | Glycerol phenylbutyrate | KSK67 | AB21 HCl |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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