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Postion:Product Catalog >S1R agonist 2 hydrochloride
S1R agonist 2 hydrochloride
  • S1R agonist 2 hydrochloride

S1R agonist 2 hydrochloride NEW

Price $97
Package 2mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: S1R agonist 2 hydrochloride Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameS1R agonist 2 hydrochloride
DescriptionCompound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
In vitroS1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly enhances NGF-induced neurite outgrowth in a dose-dependent manner; at 1 μM over 24 hours, it markedly inhibits Rotenone-induced cellular damage in SHSY5Y cells. Additionally, it offers neuroprotection against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours. This compound exhibits no cytotoxicity in A549, LoVo, and Panc-1 cells at varying concentrations (0-10 μM) and durations (24-72 h) [1].
In vivoCompound 8b (S1R agonist 2; 0.1-50 μM; 120 h) hydrochloride at a concentration of 10 μM does not induce embryonic mortality (100% survival of embryos), yet at the highest dosage (50 μM), it induces death in all embryos [1].
StorageShipping with blue ice.
Inhibitors RelatedKB-5492 free base | Cutamesine dihydrochloride | Blarcamesine hydrochloride | Amitriptyline hydrochloride | S1R agonist 2 | Ditolylguanidine | Sigma-1 receptor antagonist 1 | Glycerol phenylbutyrate | KSK67 | AB21 HCl

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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