(S)-Thalidomide NEW
| Price | $56 | $89 | $197 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (S)-Thalidomide | CAS No.: 841-67-8 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (S)-Thalidomide |
| Description | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic, and pro-apoptotic activities, used in studying leprosy erythema nodosum and myeloma. |
| In vitro | In U266 cells cultured with (S)-Thalidomide, a decrease in cell viability (IC50: 362 μM) was observed, reflecting a significant increase in apoptosis (for example, on the 3rd day at 200 μM: 40.3+/-3.1% vs. 3.2+/-0.4% on the 0th day; P<0.001). Furthermore, the expression profile of genes involved in angiogenesis and apoptosis changed, with the most significant alterations observed in the expression of apoptosis-related genes[1]. |
| In vivo | Direct exposure of embryos to (S)-Thalidomide does indeed result in limb reduction defects in chick embryos. (S)-Thalidomide affects chick limb transplantation into host embryos in a dose-dependent manner. Moreover, S-thalidomide and S-EM12 are more teratogenic than R-thalidomide and R-EM12[2]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (232.35 mM), Sonication is recommended. |
| Keywords | (S) Thalidomide | Thalidomide | (S)Thalidomide |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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