(S)-Coriolic acid NEW
| Price | $1450 |
| Package | 500μg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (S)-Coriolic acid | CAS No.: 29623-28-7 |
| Purity: 97.67% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (S)-Coriolic acid |
| Description | (S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage. |
| In vitro | (S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3] |
| In vivo | (S)-Coriolic acid (0-0.6 mg; intranasal; once daily for 3 consecutive days; mouse) induces significant airway dysfunction, neutrophilia, mitochondrial dysfunction, and epithelial injury.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : >50 mg/mL (per Rao Maddipati) DMSO : 55 mg/mL (185.54 mM) PBS (pH 7.2) : 1 mg/mL DMF : >50 mg/mL (per Rao Maddipati) |
| Keywords | 13HODE | Coriolic acid |
| Inhibitors Related | Imeglimin hydrochloride | Rotenone | Daidzein | Resveratrol | Fenofibrate | 5-Aminosalicylic Acid | Malotilate | Naringenin | 2,3-Butanediol |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Mitochondria-Targeted Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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