Rubiadin-1-methyl ether NEW
| Price | $40 | $156 | $278 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Rubiadin-1-methyl ether | CAS No.: 7460-43-7 |
| Purity: 98.32% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Rubiadin-1-methyl ether |
| 描述 | Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65. |
| 體外活性 | To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 2.68 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | Inhibitor | Nuclear factor-kappaB | Nuclear factor-κB | NF-κB | Rubiadin1methyl ether | Rubiadin 1 methyl ether | inhibit | Rubiadin-1-methyl ether |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥單體化合物庫(kù) | 稀有天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗感染天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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