(RS)-(Tetrazol-5-yl)glycine NEW
| Price | $36 | $58 | $143 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: (RS)-(Tetrazol-5-yl)glycine | CAS No.: 138199-51-6 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | (RS)-(Tetrazol-5-yl)glycine |
| Description | (RS)-(Tetrazol-5-yl)glycine (LY 285265) [(D,L-(tetrazol-5-yl)glycine] is an effective and selective N-methyl-D-aspartate receptor agonist with EC50s of 99 nM for GluN1/GluN2D and 1.7 μM for GluN1/GluN2A. |
| In vitro | (RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
| In vivo | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : < 1.43 mg/mL (10 mM, insoluble or slightly soluble) |
| Keywords | LY285265 | Fos | iGluR | GluN2D | (RS)-(Tetrazol-5-yl)glycine | Ionotropic glutamate receptors | inhibit | LY-285265 | Inhibitor | (RS)(Tetrazol5yl)glycine | GluN1 | (RS) (Tetrazol 5 yl)glycine | GluN2A | NMDA | seizure |
| Inhibitors Related | Mephenesin | Decanoic Acid | L-Glutamic acid | glycine | Halothane | L-Glutamic acid monosodium salt | Riluzole | D-Cycloserine | Piracetam | Linalool | O-Phospho-L-serine | Procaine hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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