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Postion:Product Catalog >Biochemical Engineering>Plant extracts>Rottlerin
Rottlerin
  • Rottlerin

Rottlerin NEW

Price $35 $55 $118
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Rottlerin CAS No.: 82-08-6
Purity: 99.44% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameRottlerin
DescriptionRottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
In vitroRottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2].
In vivoRottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 2 mg/mL (3.87 mM), Sonication is recommended.
Keywordsinhibit | NSC94525 | Inhibitor | Human immunodeficiency virus | Autophagy | Protein kinase C | Apoptosis | NSC-94525 | HIV | NSC-56346 | NSC56346 | PKC | Rottlerin
Inhibitors RelatedStavudine | 5-Fluorouracil | Emtricitabine | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Hydroxychloroquine | Lamivudine | Tributyrin | Oxyresveratrol | Gefitinib | Oleic acid
Related Compound LibrariesAnti-Tumor Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Viral Compound Library | Anti-infective Natural Product Library | TGF-beta/Smad Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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