Rotigaptide TFA(355151-12-1 free base) NEW
| Price | $81 | $239 | $359 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Rotigaptide TFA(355151-12-1 free base) | Purity: 99.21% |
| Supply Ability: 10g | Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Rotigaptide TFA(355151-12-1 free base) |
| 描述 | Rotigaptide TFA(355151-12-1 free base) is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide TFA(355151-12-1 free base) prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. |
| 體外活性 | Rotigaptide TFA (100 nM; 24 hours) does not affect INS-1 cell apoptosis itself. Rotigaptide (100 nM; 24 hours) has a positive effect on the cycloheximide-mediated decrease in Cx43 protein levels in cultured neonatal ventricular myocytes. And it obviously decreases apoptosis in cytokine-exposed cells ~10% at IL-1b concentrations above 15 pg/ml in rat insulin-producing INS-1 cells [1][2]. |
| 體內(nèi)活性 | Rotigaptide TFA (intravenous administration; 300 mg/kg; single dose) treatment in mice and rats does not cause toxicity in either species. Rotigaptide (continuous intravenous infusion; 5-14 days) in rats (100 mg/kg) and dogs (10 mg/kg) is well tolerated and produces no compound-related effects or histological toxicological findings in escalating dose studies [3]. |
| 存儲(chǔ)條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 7.32 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | Rotigaptide TFA(355151 12 1 free base) | Rotigaptide TFA(355151121 free base) | Rotigaptide TFA(355151-12-1 free base) |
| 相關(guān)產(chǎn)品 | Meclofenamic acid sodium | Carvedilol phosphate hemihydrate | Meclofenamic acid | Gap 27 | Gap 26 | Danegaptide Hydrochloride | TAT-Gap19 acetate | Larazotide acetate | Carbenoxolone disodium | Gap19 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) | 細(xì)胞骨架化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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